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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS3
All Species:
19.09
Human Site:
S110
Identified Species:
38.18
UniProt:
O14543
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14543
NP_003946.3
225
24770
S110
S
L
Q
S
D
P
R
S
T
Q
P
V
P
R
F
Chimpanzee
Pan troglodytes
XP_509267
198
22155
S85
S
D
Y
L
L
T
I
S
V
K
T
S
A
G
P
Rhesus Macaque
Macaca mulatta
XP_001106015
576
62574
S461
S
L
Q
S
D
P
R
S
T
Q
P
V
P
R
F
Dog
Lupus familis
XP_848851
225
24779
S110
S
L
Q
S
D
P
R
S
T
Q
P
V
P
R
F
Cat
Felis silvestris
Mouse
Mus musculus
O35718
225
24758
S110
S
L
Q
S
D
P
R
S
T
Q
P
V
P
R
F
Rat
Rattus norvegicus
O88583
225
24790
S110
S
L
Q
S
D
P
R
S
T
Q
P
V
P
R
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516256
214
23730
C101
R
I
Q
C
E
G
G
C
F
S
L
Q
S
D
P
Chicken
Gallus gallus
Q90X67
209
23158
Q96
G
T
K
N
L
R
I
Q
C
E
G
G
S
F
S
Frog
Xenopus laevis
P13116
532
59718
I213
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
S
Zebra Danio
Brachydanio rerio
NP_998469
210
23421
N97
K
T
A
T
G
T
K
N
L
R
I
Q
C
D
S
Tiger Blowfish
Takifugu rubipres
NP_001072096
201
22742
I88
R
H
L
F
A
L
S
I
K
T
A
S
G
T
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799032
227
25956
L110
R
I
E
Y
E
D
G
L
F
M
L
D
S
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
38.5
97.7
N.A.
96.8
95.5
N.A.
79.5
84
20.1
61.3
57.3
N.A.
N.A.
N.A.
35.2
Protein Similarity:
100
45.3
38.8
99.1
N.A.
97.3
96.4
N.A.
86.2
88.4
28.2
74.6
70.6
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
6.6
0
6.6
0
0
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
20
20
6.6
26.6
0
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
9
0
0
0
0
0
9
0
9
0
0
% A
% Cys:
0
0
0
9
0
0
0
9
9
0
0
0
9
0
0
% C
% Asp:
0
17
0
0
42
9
0
0
0
0
0
9
0
17
0
% D
% Glu:
0
0
9
0
17
0
0
0
0
9
0
0
0
9
9
% E
% Phe:
0
0
0
9
0
9
0
0
17
0
0
0
0
17
42
% F
% Gly:
9
0
0
9
17
9
17
0
0
0
9
9
9
9
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
17
0
0
0
0
17
17
0
0
9
0
0
0
0
% I
% Lys:
9
0
9
0
0
0
9
0
9
9
0
0
0
0
9
% K
% Leu:
9
42
9
9
17
9
0
9
9
0
17
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
42
0
0
0
0
42
0
42
0
17
% P
% Gln:
0
0
50
0
0
0
0
9
0
42
0
17
9
0
0
% Q
% Arg:
25
0
0
0
0
9
42
0
0
9
9
0
0
42
0
% R
% Ser:
50
0
9
42
0
0
9
50
0
17
0
17
25
0
25
% S
% Thr:
0
17
0
9
0
17
0
0
50
9
9
9
0
9
0
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
42
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
9
0
0
9
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _